Centuries of scientific progress have been devoted to reducing uncertainty. Newtonian physics, introduced over 300 years ago, allowed for precise prediction of planetary and tidal motion, falling bodies and infinitely more, in addition to allowing the construction of the material world. The 20th century witnessed a revolution in our understanding of organ and cellular function and dysfunction, elucidation of pathways, mediators, receptors, and molecular interactions, and breakthroughs in the characterization of replication, transcription, and translation, all of which has been integral (...) to our understanding of human physiology and pathophysiology. Clinical epidemiology has had a revolutionary impact on our .. (shrink)

Prior generations’ electoral crises (e.g., gerrymandering) have dealt mainly with political maneuverings around geographical shifts. We analyze four recent (1998–2003) American electoral crises: the Clinton impeachment controversy, the 2000 Florida presidential election, the Texas legislators’ flight to Oklahoma and New Mexico, and the California gubernatorial recall. We show that in each case temporal manipulation was at least as important as geographical. We highlight emergent electoral practices surrounding the manipulation of time, which we dub “temporal gerrymandering.” We suggest a theory of (...) postmodern electoral crises, in which the rules of time and space are simultaneously in flux. These crises expose concerns with early American democratic theory, which was based on an understanding of “the people” as geographically and temporally unidimensional. Representative systems, therefore, were designed largely without reference to geographic and temporal complexity. (shrink)

At extreme altitude (>5,000 – 5,500 m), sustained hypoxia threatens human function and survival, and is associated with marked involuntary weight loss (cachexia). This seems to be a coordinated response: appetite and protein synthesis are suppressed, and muscle catabolism promoted. We hypothesise that, rather than simply being pathophysiological dysregulation, this cachexia is protective. Ketone bodies, synthesised during relative starvation, protect tissues such as the brain from reduced oxygen availability by mechanisms including the reduced generation of reactive oxygen species, improved mitochondrial (...) efficiency and activation of the ATP‐sensitive potassium (KATP) channel. Amino acids released from skeletal muscle also protect cells from hypoxia, and may interact synergistically with ketones to offer added protection. We thus propose that weight loss in hypoxia is an adaptive response: the amino acids and ketone bodies made available act not only as metabolic substrates, but as metabolic modulators, protecting cells from the hypoxic challenge.Also watch the Video Abstract. (shrink)

The use of Big Data—however the term is defined—involves a wide array of issues and stakeholders, thereby increasing numbers of complex decisions around issues including data acquisition, use, and sharing. Big Data is becoming a significant component of practice in an ever-increasing range of disciplines; however, since it is not a coherent “discipline” itself, specific codes of conduct for Big Data users and researchers do not exist. While many institutions have created, or will create, training opportunities to prepare people to (...) work in and around Big Data, insufficient time, space, and thought have been dedicated to training these people to engage with the ethical, legal, and social issues in this new domain. Since Big Data practitioners come from, and work in, diverse contexts, neither a relevant professional code of conduct nor specific formal ethics training are likely to be readily available. This normative paper describes an approach to conceptualizing ethical reasoning and integrating it into training for Big Data use and research. Our approach is based on a published framework that emphasizes ethical reasoning rather than topical knowledge. We describe the formation of professional community norms from two key disciplines that contribute to the emergent field of Big Data: computer science and statistics. Historical analogies from these professions suggest strategies for introducing trainees and orienting practitioners both to ethical reasoning and to a code of professional conduct itself. We include two semester course syllabi to strengthen our thesis that codes of conduct can be harnessed to support the development of ethical reasoning in, and a sense of professional identity among, Big Data practitioners. (shrink)

Recent research (Latham, Miller and Norton, forthcoming) reveals that a majority of people represent actual time as dynamical. But do they, as suggested by McTaggart and Gödel, represent time as essentially dynamical? This paper distinguishes three interrelated questions. We ask (a) whether the folk representation of time is sensitive or insensitive: i.e., does what satisfies the folk representation of time in counterfactual worlds depend on what satisfies it actually—sensitive—or does is not depend on what satisfies it actually—insensitive, and (b) do (...) those who represent actual time as dynamical, represent time in all possible worlds as dynamical—what we call insensitive dynamism—or do they represent time in all possible worlds as dynamical only conditional on the actual world in fact being dynamical—what we call sensitive dynamism and (c) do dynamists and non-dynamists deploy two different representations of time, or deploy the same representation, but disagree about what actually satisfies that representation? We found no evidence that the folk representation of time is sensitive, or that the folk representation of time is essentially dynamical in either sense, though we did find evidence of a shared representation, on which dynamical features are sufficient, but not necessary, for time. (shrink)

Morsella et al. argue that science should not focus on high forms of consciousness. We disagree. An understanding of high forms of consciousness is invaluable to the scientific study of consciousness. Moreover, it poses challenges to the passive frame theory. Specifically, it challenges the notions that conscious thoughts are not connected and that consciousness serves skeletomotor conflict only.

Four experiments supported the hypothesis that ordinary people understand free will as meaning unconstrained choice, not having a soul. People consistently rated free will as being high unless reduced by internal constraints (i.e., things that impaired people’s mental abilities to make choices) or external constraints (i.e., situations that hampered people’s abilities to choose and act as they desired). Scientific paradigms that have been argued to disprove free will were seen as reducing, but usually not eliminating free will, and the reductions (...) were because of constrained conscious choice. We replicated findings that a minority of people think lacking a soul reduces free will. These reductions in perceived free will were fully explained by reductions in people’s perceived abilities to make conscious decisions. Thus, some people do think you need a soul to have free will—but it is because they think you need a soul to make conscious decisions. (shrink)

Boarding school is a major educational option for many students (e.g., students living in remote areas, or whose parents are working interstate or overseas, etc.). This study explored the motivation, engagement, and achievement of boarding and day students who are educated in the same classrooms and receive the same syllabus and instruction from the same teachers (thus a powerful research design to enable unique comparisons). Among 2,803 students (boardingn= 481; dayn= 2,322) from 6 Australian high schools and controlling for background (...) attributes and personality, we found predominant parity between boarding and day students in their motivation, engagement, and achievement. We also found that classroom-average motivation, engagement, and achievement was not significantly affected by the number of boarders (relative to day students) in the classroom. In addition, the effects of boarding were generally not moderated by students’ background or personality attributes. We conclude that boarders have academic opportunities and outcomes that are comparable to their day student counterparts. Implications for students, teachers, and parents are discussed. (shrink)

_ Source: _Volume 46, Issue 1, pp 70 - 97 In 1946 Heidegger suffered a mental breakdown and received treatment by Dr. Viktor Emil Freiherr von Gebsattel. I explore the themes of health and help in Heidegger’s work before and after his treatment. I begin with Heidegger’s views on health while Rector in 1933–34 and his abandonment of these views by war’s end. A short while later, Heidegger’s breakdown occurs and the treatment under Gebsattel begins. Soon after his treatment, Heidegger (...) lauds what he terms a “broken-down” thinking, and I examine his contribution to a 1958 _Festschrift_ for Gebsattel to better articulate such a thinking. Lastly, I take up Heidegger’s remarks on the role of the medical profession in a technological age from a 1962 speech. In presenting this material, I hope to shed new light on a little known aspect of Heidegger’s career and biography and to situate philosophically his relationship with Dr. Gebsattel. (shrink)

L’imamat et l’occultation selon l’imamisme: Étude bibliographique et histoire des textes. By Hassan Ansari. Islamic History and Civilization, vol. 134. Leiden: Brill, 2017. Pp. xx + 310 + 268. $245, €204.

An Enquiry into the Nature of Liberation: Bhaṭṭa Rāmakaṇṭha’s Paramokṣanirāsakārikāvṛtti, a Commentary on Sadyojyotiḥ’s Refutation of Twenty Conceptions of the Liberated State. Edited and translated by Alex Watson, Dominic Goodall, and S. L. P. Anjaneya Sarma. Collection Indologie, vol. 122. Pondicherry: Institut Français de Pondichéry, École française d’Extrême-Orient, 2013. Pp. 508. €38.

In the foreground of Father Lonergan's analysis of the cognitional process are insight and the heuristic structures it employs. A close study of paradigms of insight exhibits mental acts apprehending intelligibilities logically distinct from, though psychologically conveyed by sense data and images. Because these intelligibilities, e.g., in contemporary physics, bear witness to entities which are unimaginable, knowing is not merely looking. Knowing involves entertaining intelligible meanings and reflecting on them, and though it exists, for men at least, within the boundaries (...) of sensible experience, knowing in its primary activity as insight goes beyond the empirical presentations to grasp intelligible meanings and to judge reflectively their truth or falsity. When judging, a rational self-consciousness affirms a proposition, i.e., an intelligible meaning, in view of its sufficient reason or grounds. In this sense affirmative judgment renders the conditioned "virtually unconditioned" by linking it up with its conditions, as structures immanent and operative within the cognitional process effectuate this linkage of the conditioned with its conditions. These structures, which Father Lonergan supposes he can express as rules for the construction of situations which give rise to insight so that method and not genius suffices to gain truth, are held to be constitutive of the acts of insight and understanding. Accordingly, the positive content of Insight is summed up in the slogan: "Thoroughly understand what it is to understand, and not only will you understand the broad lines of all there is to be understood but also you will possess a fixed base, an invariant pattern, opening upon all further developments of understanding". (shrink)

Philosophers working on time-biases assume that people are hedonically biased toward the future. A hedonically future-biased agent prefers pleasurable experiences to be future instead of past, and painful experiences to be past instead of future. Philosophers further predict that this bias is strong enough to apply to unequal payoffs: people often prefer less pleasurable future experiences to more pleasurable past ones, and more painful past experiences to less painful future ones. In addition, philosophers have predicted that future-bias is restricted to (...) first-person preferences, and that people’s third-person preferences are time-neutral. Philosophers disagree vigorously about the normative status of these preferences—i.e., they disagree about whether first-person future-bias is rationally permissible. Time-neutralists, for example, have appealed to the predicted asymmetry between first- and third-person preferences to argue for the rational impermissibility of future-bias. We empirically tested these predictions, and found that while people do prefer more past pain to less future pain, they do not prefer less future pleasure to more past pleasure. This was so in both first and third-person conditions. This suggests that future-bias is typically non-absolute, and is more easily outweighed in the case of positive events. We connect this result to the normative debate over future-bias. (shrink)

This paper is a preliminary investigation into the application of the formal-logical theory of normative positions to the characterisation of normative-informational positions, pertaining to rules that are meant to regulate the supply of information. First, we present the proposed framework. Next, we identify the kinds of nuances and distinctions that can be articulated in such a logical framework. Finally, we show how such nuances can arise in specific regulations. Reference is made to Data Protection Law and Contract Law, among others. (...) The proposed approach is articulated around two essential steps. The first involves identifying the set of possible interpretations that can be given to a particular norm. This is done by using formal methods. The second involves picking out one of these interpretations as the most likely one. This second step can be resolved only by using further information (e.g., the context or other parts of the regulation). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Faulkner's Novels Past and PresentAndrew J. McKenna (bio)This article contains instances of the N-word. The Editor, Michigan State University Press, and Michigan State University do not condone the use of this word and only after careful consideration have we reprinted it. In this case, the word appears in the context of works by Faulkner.When I first came East I kept thinking You've got to remember to think of some (...) of them as coloured people not niggers, … I learned that the best way to take all people, black or white, is to take them for what they think they are, and leave them alone. That was when I realized that a nigger is not a person so much as a form of behavior; a sort of obverse reflection of the white people he lives among.—Faulkner, The Sound and the Fury ([1929] 2019, 45)A black man is a person who must ride Jim Crow in Georgia.—W. E. B. Du Bois ([1940] 1992, 153)When William Faulkner memorably stated, "the past is not dead, it's not even past," he was not reaching out for a place in the world-historical pantheon of aphoristic wisdom; he wasn't thinking about culture and history in general. A person of his own time and place, he was thinking about his experience in his own homeland, the deep South of his native [End Page 39] Mississippi, with its cherished myth of a Lost Cause that ennobled the effort to tear our country apart over slavery, and that subsequently enabled Jim Crow legislation, spawned the KKK, and sanctioned a century of lynching and burning. There has been an uptick of attention to Faulkner owing to Carl Rollyson's recent two-volume biography (2020) and, especially for my purposes, Michael Gorra's The Saddest Words: William Faulkner's Civil War (2020), which focuses on the centrality of that cataclysm in his creative imagination and his historical vision.On more than one occasion Faulkner himself was emphatic in his own ambivalence toward "his native land," as in this self-description: "He was born of it and his bones will sleep in it; loving it even while hating some of it … the intolerance and injustice; the lynching of negroes not for the crimes they committed but because their skins were black" (in Blotner 2005, 354). Gorra (2020) argues that this very ambivalence is a generative resource for the author's greatest achievements, quoting Yeats's notorious dictum, "We make out of the quarrel with others, rhetoric, but of the quarrel with ourselves, poetry" (346). This can remind us of the notorious "crucible of doubt" out of which Dostoevsky allegedly forged his fiction. The Russian novelist is named (Blotner 2005, 718) as among seven of Faulkner's "masters" in the literary education of this omnivorous autodidact, with the others being Melville, Conrad, Balzac, Flaubert, Dickens, and Cervantes. With Dostoevsky especially he shares an admixture of horror and benign good humor. On occasion Faulkner was classed as an author of Southern Gothic, a label also applied to Flannery O'Connor, who, with Toni Morrison and Cormac McCarthy, counts among his greatest literary progeny. A more capacious designation might rank him with masters of the grotesque, as Mikhail Bakhtin has explored this anomalous category in his writings on Rabelais and Dostoevsky.Light in August (Faulkner, 1932) begins and ends on a humorous note, as we follow the quest of the guileless Lena Grove for the father of her unborn child. She has concluded from her "endless care of other children" in her brother's household, "'I reckon that's why I got one so quick myself'" (3); the novel closes with her newborn infant in her arms in her now aimless trek, marveling, "My, my. A body does get around: here we aint been coming from Alabama but two months, and now it's already Tennessee" (480).Lena's peregrinations bookend the story of Joe Christmas, so named because he was born on that day and who, we find later in the narrative, was snatched away by his religiously fanatical grandfather to be placed in an orphanage, then snatched away again to be placed... (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The devastating toll of gun violence has given rise to hundreds of lawsuits seeking justice on behalf of victims and their families. A significant number of challenges against gun companies, however, are blocked by courts' broad reading of the Protection of Lawful Commerce in Arms Act — a federal statute often interpreted to shield the gun industry from civil liability. This article reexamines PLCAA in light of the Supreme Court's recent federalism caselaw, which counsels courts to narrowly construe federal laws (...) that could otherwise upset the balance of power between states and the federal government. Since PLCAA infringes on traditional areas of state authority, the Supreme Court's federalism jurisprudence requires lower courts to interpret PLCAA narrowly, to not bar states from imposing negligence, nuisance, product liability, or other common law liability on gun companies. Reading PLCAA in line with federalism principles would preserve states' traditional authority over their civil justice laws, and enable gun violence victims, and their families, to hold gun companies responsible for wrongdoing. (shrink)

Empirical evidence suggests that people naïvely represent time as dynamical (i.e. as containing robust temporal passage). Yet many contemporary B-theorists deny that it seems to us, in perceptual experience, as though time robustly passes. The question then arises as to why we represent time as dynamical if we do not have perceptual experiences which represent time as dynamical. We consider two hypotheses about why this might be: the temporally asperspectival replacement hypothesis and the moving open future hypothesis. We then empirically (...) test the moving open future hypothesis. According to that hypothesis we represent the past as objectively fixed and the future open. And we represent that this objective openness moves as events that were open, become fixed such that in doing so we represent a privileged moving present. We found no evidence for the moving open future hypothesis, which suggests that further investigation of the temporally asperspectival replacement hypothesis is called for. Our results also shed further light on our understanding of the respects in which we represent the future to be open, which, in turn, has implications for our theorising about the open future. (shrink)

This is the first book to offer the best essays, articles, and speeches on ethics and intelligence that demonstrate the complex moral dilemmas in intelligence collection, analysis, and operations. Some are recently declassified and never before published, and all are written by authors whose backgrounds are as varied as their insights, including Robert M. Gates, former Director of the Central Intelligence Agency; John P. Langan, the Joseph Cardinal Bernardin Professor of Catholic Social Thought at the Kennedy Institute of Ethics, Georgetown (...) University; and Loch K. Johnson, Regents Professor of Political Science at the University of Georgia and recipient of the Owens Award for contributions to the understanding of U.S. intelligence activities. Creating the foundation for the study of ethics and intelligence by filling in the gap between warfare and philosophy, this is a valuable collection of literature for building an ethical code that is not dependent on any specific agency, department, or country. (shrink)

How do people understand the concepts of mental health and disorder? The objective of this paper is to examine the impact of several factors on people’s judgments about whether a condition constitutes a mental disorder or a healthy state. Specifically, this study examines the impact of the source of the condition, its outcome, individual valuation (i.e., the value the individual attaches to the condition), and group valuation (i.e., the value the relevant group attaches to the condition). While we find that (...) people’s health and disorder judgments are driven by perceived dysfunction, we also find that health and disorder judgments are impacted differently by these factors. Health judgements are impacted by outcome and individual valuation, and disorder judgments are impacted by condition source. These results suggest that the folk concept of mental health is positive (i.e., mental health is more than the absence of mental disorder) and normativist (i.e., value judgments play a significant role in determining whether a condition counts as healthy), while the concept of mental disorder aligns with a naturalist perspective, at least to the extent that dysfunction plays an important role in categorizing a condition as a disorder. However, our finding that people’s dysfunction judgments are influenced by individual valuation and outcomes poses a strong challenge to naturalist accounts. To provide access to our supplementary data, an appendix has been included. (shrink)

Preston Greene (2020) argues that we should not conduct simulation investigations because of the risk that we might be terminated if our world is a simulation designed to research various counterfactuals about the world of the simulators. In response, we propose a sequence of arguments, most of which have the form of an "even if” response to anyone unmoved by our previous arguments. It runs thus: (i) if simulation is possible, then simulators are as likely to care about simulating simulations (...) as they are likely to care about simulating basement (i.e. non-simulated) worlds. But (ii) even if simulations are interested only in simulating basement worlds the discovery that we are in a simulation will have little or no impact on the evolution of ordinary events. But (iii) even if discovering that we are in a simulation impacts the evolution of ordinary events, the effects of seeming to do so could also happen in a basement world, and might be the subject of interesting counterfactuals in the basement world Finally, (iv) there is little reason to think that there is a catastrophic effect from successful simulation probes, and no argument from the precautionary principle can be used to leverage the negligible credence one ought have in this. Thus, if we do develop a simulation probe, then let’s do it. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Self Between: From Freud to the New Social Psychology of FranceAndrew J. McKennaThe Self Between: From Freud to the New Social Psychology of France, by Eugene Webb; ix & 268 pp. Seattle: University of Washington Press, 1993, $35.00.That psychology and sociology are one science is the fundamental premise guiding Eugene Webb’s The Self Between, which he defines early on as “a self constituted dynamically and continuously by (...) the relationships it finds itself involved i n.” The “new social psychology of France” designated by his subtitle is mostly the one inspired by René Girard’s mimetic model of human behavior, to which four of Webb’s seven chapters are specifically devoted.Girard’s idea, which he learned from our literary masterpieces, is that human desire is mimetic, that it imitates other desires in its choice of objects and in pursuit of their possession. As desires converge on a single object, the locus of conflict will be between subjects rather within their individual psyches, a consequence that motivates Girard’s ongoing critique of Freudian psychoanalysis.But Freud’s theories are everywhere disputed in this book, which reports reliably on the devastating critiques advanced by François Roustang, Marie Balmary, and Mikkel Borch-Jacobsen. Roustang has convincingly (and entertainingly) uncovered Freud’s blindness to the pathologies of transference and discipleship investing the foundation of psychoanalysis. A pattern of rivalry for recognition and preeminence guides Freud’s career in a way that is reenacted around Lacan. Balmary, somewhat a Lacanian her self, has turned psychoanalytic theory against Freud to explore his own family secrets, while severely questioning the master’s bid for a universal theory pursued via self-analysis amidst a period of emotional upheaval. And Borch-Jacobsen has shown how th e dynamics of hypnosis that Freud rejected early on were brought back as transference, while arguing for his own part that mimetic identification with the other, rather than any primordial drives, is what brings the subject into being. These informat ive chapters help bring us up to date on significant debates that have developed since Lacan drew the French intellectual world, and so many Americans after it, into the orbit of psychoanalysis.But by far the bulk of Webb’s attention goes to Girard’s work and to that of [End Page 191] scholars and practitioners who have sought to extend it further in the social sciences. Principle among them is Jean-Michel Oughourlian, whose Puppet of Desire (translated by Webb in 1991) demonstrates how the mimetic model plays out in psychotherapy, notably in the workings of hypnotism and somnambulism, in cases of demonic possession, and in obsessional neurosis. In each case, the subject is unwitt ingly captive of another’s desire in a way that produces behavioral anomalies and disorders that are nonetheless available to lucid, jargon-free diagnosis. What is appealing here is the deployment of a rational explanation for irrational behavior, once we grasp the paradoxical rationale of desire; equally appealing prospects of actual healing are outlined here and at the end of the book, where possibilities of freedom and responsibility are resurrected from a technical vocabulary that smothers them.Girard’s idea of the self as relation, as interdividuality, rather than as a discreet unit, has social and political dimensions to which we only find tantalizing allusions in his works. They have been pursued with acumen by such writers as André Orléan, Paul Dumouchel and especially Jean-Pierre Dupuy, who figures importantly among those aligning systems theory with theories of social and economic organization. Like Borch-Jacobsen and Roustang, Dupuy restores due attention to concep tions of crowd behavior outlined at the end of the last century by Tarde and Le Bon, whose best insights Freud studiously discarded.This is richly interdisciplinary work, strongly suggesting that we variously redraw and erase lines defining academic fields. Occam’s razor flicks often and decisively in these pages, which restore needed balance to the effects of some wild er French imports. Webb brings no new ideas of his own to this capable synthesis, but his accurate report will help guide researchers toward major recent developments in France around and mostly beyond Freudian psychoanalysis... (shrink)

This collection of writings by E.S. Brightman is a worthy representation of the intellectual dimensions and philosophical achievements of the man who led the personalist movement in his lifetime and who served as Borden Parker Bowne Professor of Philosophy at Boston University from 1924 until 1953. The volume contains twenty-one selections, consisting of journal articles, book chapters, published lectures and addresses; they are arranged in seven subdivisions: Person, Knowledge, and Reality; Persons and Theory of Value; Philosophy of Religion; On Bowne’s (...) Personalism; Of Persons and Philosophies; Latin American Thought; and Personalism and Life. Each part is meaty in its own way. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

Conditional information can be equally asserted in the forms if p, then q (e.g., ?if I am ill, I will miss work tomorrow?) and q, if p (e.g., ?I will miss work tomorrow, if I am ill?). While this type of clause order manipulation has previously been found to have no influence on the ultimate conclusions participants draw from conditional rules, we used self-paced reading to examine how it affects the real time incremental processing of everyday conditional statements. Experiment 1 (...) revealed that clause order interacts with presuppositional congruency as readers hypothetically represent counterfactual statements. When if p, then q counterfactuals contained a presupposition that was incongruent with prior context, these statements took longer to read than when the presupposition was congruent, but for q, if p conditionals there was no such congruency effect. Experiment 2 revealed that reading times were influenced by the subjective probability of an indicative conditional regardless of clause order, with a penalty observed for low-probability statements relative to high-probability statements in both conditional clause orders. These data reveal a dissociation whereby clause order mediates the effect of suppositional congruency on reading times, but does not mediate the effect of subjective probability. (shrink)

Perception of music and speech is based on similar auditory skills, and it is often suggested that those with enhanced music perception skills may perceive and learn novel words more easily. The current study tested whether music perception abilities are associated with novel word learning in an ambiguous learning scenario. Using a cross-situational word learning (CSWL) task, nonmusician adults were exposed to word-object pairings between eight novel words and visual referents. Novel words were either non-minimal pairs differing in all sounds (...) or minimal pairs differing in their initial consonant or vowel. In order to be successful in this task, learners need to be able to correctly encode the phonological details of the novel words and have sufficient auditory working memory to remember the correct word-object pairings. Using the Mistuning Perception Test (MPT) and the Melodic Discrimination Test (MDT), we measured learners’ pitch perception and auditory working memory. We predicted that those with higher MPT and MDT values would perform better in the CSWL task and in particular for novel words with high phonological overlap (i.e., minimal pairs). We found that higher musical perception skills led to higher accuracy for non-minimal pairs and minimal pairs differing in their initial consonant. Interestingly, this was not the case for vowel minimal pairs. We discuss the results in relation to theories of second language word learning such as the Second Language Perception model (L2LP). (shrink)

_341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...) combined gold standard QCA plus FFR in patients with multivessel disease. _Methods: _FFR and QCA of 95 vessels in 80 patients have been evaluated. Hemodynamically significant target lesions were defined as intermediate stenoses between 50 and 75% with an FFR. (shrink)

Thomas Jefferson and Philosophy: Essays on the Philosophical Cast of Jefferson’s Writings is a collection of essays on topics that relate to philosophical aspects of Jefferson’s thinking over the years. Much historical insight is given to ground the various philosophical strands in Jefferson’s thought and writing on topics such as political philosophy, moral philosophy, slavery, republicanism, wall of separation, liberty, educational philosophy, and architecture.

This book presents a collection of contemporary discourses that reconsider the relationship of democracy as a political ideology and American ideal and education as the foundation of preparing democratic citizens in America.

Controversy and activism have long been linked to the subject of primate research. Even in the midst of raging ethical debates surrounding fertility treatments, genetically modified foods and stem-cell research, there has been no reduction in the campaigns of activists worldwide. Plying their trade of intimidation aimed at ending biomedical experimentation in all animals, they have succeeded in creating an environment where research institutions, often painted as guilty until proven innocent, have avoided addressing the issue for fear of becoming targets. (...) One area of intense debate is the use of primates in stroke research. Despite the fact that stroke kills more people each year than AIDS and malaria, and less than 5% of patients are candidates for current therapies, there is significant opposition to primate stroke research. A balanced examination of the ethics of primate stroke research is thus of broad interest to all areas of biomedical research. (shrink)

Meaningful relationships are centrally important for human functioning. It remains unclear, however, which aspects of meaningful relationships impact wellbeing the most and whether these differ between psychiatric patients and members of the community. Information about relationship attributes and functions were collected in community members and psychiatric patients. Relationship attributes and functions were examined for differences between groups, their impact on wellbeing and symptoms, and the size of network. Community members reported fewer relationships, higher frequency of contact and less desire for (...) change when compared to the psychiatric patients. Nevertheless, both groups reported relatively high levels of fulfilled functions. Quality of the relationship and investment into the relationship was associated with both wellbeing and symptoms for both the community and the patient group. Almost all functions were associated with wellbeing and symptoms for the community group. However, for the patient group, only few functions were associated with wellbeing and no functions were associated with symptoms. Contrary to our hypotheses, the results show that psychiatric patients do not have a deficit in fulfilling relationships. Most people report a well-functioning network of meaningful, high-quality relationships. Patients benefit from meaningful, function-fulfilling relationships just as much as community members. Results are discussed with respect to how targeting relationships can be used clinically. (shrink)

Facing an increasing number and variety of issues with social salience, firms must determine how to engage with issues that likely have a significant impact on them. Integrating issues management and salience theories, the authors find that firms engage with socially contested issues—where there is a high degree of societal disagreement—in a different manner from issues that have social consensus, or high agreement. Examining social issue resolutions filed by shareholders from 1997 to 2009, the study finds that socially contested issues, (...) as well as those issues with social consensus, are both likely to result in engagement by the firm. For social issues with consensus, a firm is more likely to opt for a low level of shareholder engagement whereas resolutions regarding contested issues lead to engaging shareholders at a higher level. These findings shed new light on the IM and issue salience literature streams that have suggested firms will react differently to these types of issues, even while they remain largely untested. Finally, firms become less engaged with perennial issues over time. rather than more, providing new guidance to researchers, shareholder activists, and firms alike. To the authors’ knowledge, such fined-grained insight into expected levels of firm engagement with social issue salience has not been put forth previously. (shrink)